A simple grey theme for Thunderbird using legacy userChrome. This is a solid-colour theme using #e7e7e7 background which may help reduce eye-strain.
The blog post: Thunderbird Supernova grey theme
Works for me.
Thunderbird 115+
Enable userChrome in Thunderbird:
Locate your profile directory:
In your profile directory, create a new folder called 'chrome'.
Add userChrome.css and userContent.css to the directory 'chrome'.
Restart Thunderbird.
This project is made available under a GPL3 licence -- see COPYING for the full text.